Antibiotics are now widely prescribed in various protocols for treating COVID-19 infections, especially in severe cases. The data in the literature about the antiviral role of these antibiotics are greatly contradictory. Despite their known adverse effects on patients' health, physicians usually take into consideration the benefits versus risks ratio and insist on using them in therapeutic protocols during viral infections. Piperacillin/tazobactam, meropenem, and coamoxiclav drugs were used mainly in critical care units for COVID patients [1-3]. there should be good management while using antibiotics to prevent superinfection and resistance [4]. Moreover, physicians should always consider that a virus may be a superinfection [5]. Despite the use of doxycycline as an antiviral drug, there are some contraindications between published researches on whether or not this drug is causing serious side effects such as esophagitis, ulceration, and resistance to the drug [6]. Azithromycin was found to be effective against COVID-19 due to its antiviral and immunomodulating properties, such as decreasing the viral load and release, as well as preventing lung fibrosis so it is helpful in the treatment journey [7-9]. Many virally ill patients are taking cefepime for the claims that it has antiviral effects although when influenza A study was conducted, it proved otherwise, so more researches are needed for this drug [10]. Ceftazidime shows antiviral activity against COVID-19 so it should be considered as the first drug of choice according to Chang Dong et al [11]. Although fluoroquinolones have antiviral effects and showed effectiveness against CMV, VZV, HSV-1, HSV-2, HCV, and HIV, their side effects are wild and serious since they affect the nervous system, tendons, and joints [12-13]. However, other researchers state that some types of them are the best antibiotics to be used for COVID due to their pharmacokinetic profile [12]. A study aimed to measure the changes and patterns of national antimicrobial use for one year preceding and one year during the COVID-19 pandemic in Jordan reported that there was an increase in the use of several antibiotics during 2020 compared with 2019. Third-generation cephalosporins, carbapenems, macrolides, and lincosamides are the most frequently used drug and cephalosporins the least. In 2020 there was a marked reduction in amoxicillin and on the other hand, the use of azithromycin highly increased. Moreover, there was an increase in using hydroxychloroquine in 2020 compared with 2019 [14].

Based on the aforementioneddata, it is obvious that most available antibiotics have significant activities notably potential antiviral effects. The current review highlights the different possible antiviral mechanisms that lead to their potential clinical use in COVID-19 outbreaks and focuses on the current status protocols used in Jordan compared with those worldwide.