The Burden of Diabetic Kidney Disease in Nigeria
Diabetes mellitus is a chronic metabolic disorder where reduced insulin secretion or action leads to persistent hyperglycaemia with attendant deleterious effects. It is the most common disease encountered in Endocrinology practice in Nigeria [1,2]. In Subsaharan Africa, Nigeria has the highest number of individuals living with diabetes mellitus [3]. In a meta-analysis, the pooled prevalence of diabetes mellitus among adults in Nigeria was 5.77% [4]. According to the International Diabetes Federation (IDF), the prevalence of diabetes mellitus in Nigeria, as at 2020, was 3% although studies have suggested that the burden of the disease in Nigeria was underestimated by IDF because IDF worked with extrapolated data [5]. In terms of hospitalization, about 223 individuals per 100 000 general population get admitted for diabetes and/or its complications yearly in Nigeria, out of which about 22% die [6]. Poorly treated diabetes mellitus is associated with a myriad of micro vascular and macro vascular complications. The most commonly documented micro vascular complications of diabetes mellitus are neuropathy, nephropathy and retinopathy [7].The rising prevalence of diabetes mellitus, especially type 2, in Nigeria would translate to increasing burden of micro vascular complications and this is quite worrisome as Nigeria is a low resource setting where most patients pay out of pocket [8]. Interestingly, the presence of micro vascular complications independently increases the risk of cardiovascular death in people living with diabetes [9]. This further emphasizes the importance of addressing the micro vascular complications of diabetes mellitus. In Nigeria, the third most common cause of chronic kidney disease is diabetes mellitus, after hypertension and chronic glomerulonephritis although diabetes remains the most common cause of end-stage renal disease globally [10,11]. Diabetic Kidney Disease (DKD), formerly called diabetic nephropathy, is a complication of diabetes mellitus characterized by persistent albuminuria, confirmed on a second occasion at least 3 months apart and/or progressive deterioration of the estimated glomerular filtration rate [12]. It is of remarkable importance to note that individuals diagnosed with DKD tend to die from cardiovascular diseases and infections even before renal replacement therapy is instituted [12]. The natural history of DKD is shown in Figure 1 below [13].